MBBCh, FRCPC, DSc(Med), Professor of Paediatrics, Chair Emeritus, Department of Paediatrics, University of Toronto; Paediatrtician-in-Chief Emeritus, The Hospital for Sick Children, Toronto, ON
Canada: Stuck in the middle according UNICEF child health indicators: real and potential impacts on endocrine disorders
Denis Daneman obtained his MBBCh in 1973, his FRCP(C) in 1981, and his DSc(Med), the University of the Witwatersrand’s highest degree for his thesis entitled “Contributions to type 1 diabetes in children and adolescents.” He has been on the staff at SickKids and UofT since 1981, from 1993-2006 as Head, Division of Endocrinology, 2000-2005 as Associate Chief, Clinical of the SickKids’ Research Institute and from 2006-2016 as Chair of UofT’s Department of Paediatrics and Paediatrician-in-Chief at SickKids. He has published well over 200 papers mainly in the field of diabetes in children and youth, co-authored 3 books, one of which, “When a Child has Diabetes”, has served as the major manual for Canadian families with children with recently diagnosed diabetes. He co-chaired the first diabetes clinical practice guidelines in Canada, and continues to be involved in guideline development. Denis has been involved in a number of multicenter international trials, including the DCCT, TRIGR and AdDIT. He has played leadership roles in both national (Canadian Paedaitric Endocrine Group, Canadian Diabetes Association) and international organizations (International Society for Pediatric and Adolescent Diabetes, ISPAD). He has received innumerable awards, most recently the 2010 ISPAD Prize, the 2013 Canadian Diabetes Association’s Lifetime Achievement Award and, and the 2015 Canadian Association for Academic Healthcare Centres (CAPHC) Award for Contributions to Child Health. In October 2016 he will receive an Honorary Fellowship from the Royal College of Paediatrics of Ireland.
MD, Professor Emeritus of Pediatrics and Medicine, The University of Chicago Pritzker School of Medicine, Chicago, IL USA; Adjunct Professor of Pediatrics, The University of California, San Francisco, San Francisco, CA, USA
Polycystic Ovary Syndrome (PCOS) in Adolescence
Dr Rosenfield has been a “bedside to bench” clinical investigator involved with research into pubertal disorders for nearly 50 years. Since discovering the elevated free testosterone and low sex hormone binding globulin blood levels of hirsute women in 1971, elucidating the role of androgen in normal and abnormal female reproductive endocrinology has been his primary research interest. His group’s development of the gonadotropin-releasing hormone agonist test of pituitary-ovarian function identified the characteristic steroidogenic dysfunction of polycystic ovary syndrome (PCOS), which was instrumental in identifying that the essence of this disorder is functional ovarian hyperandrogenism (FOH). Their discovery that insulin and insulin-like growth factor I up-regulate the thecal androgenic response to luteinizing hormone was a key step in developing their widely accepted hypothesis that steroidogenic dysregulation underlies the ovarian and adrenal dysfunction of FOH. Subsequently, they identified type 5 17ß-hydroxysteroid dehydrogenase as the ovarian testosterone-forming enzyme and then demonstrated a unique transcriptional link between the regulation of this enzyme and adiposity by insulin.
Endocrine Late Effects in Pediatric Cancer Survivors
Eleanor Hendershot completed her Master of Nursing in the Acute Care Nurse Practitioner Programs at the University of Toronto in 2003. She is currently working as a Nurse Practitioner at McMaster Children’s Hospital. She has a special interest in pediatric cancers survivors and the late effects of cancer treatment. She was previously the Aftercare Nurse Practitioner at both the Hospital for Sick Children and Princess Margaret Cancer Centre.
Eleanor is also cross-appointed to the Lawrence S. Bloomberg Faculty of Nursing, University of Toronto as an Adjunct lecturer. She has published several book chapters on children and adolescents with solid tumors. She has also published multiple manuscripts on pediatric solid tumors, supportive care and survivorship issues. Eleanor is a member of the Children’s Oncology Group and the nursing representative on the Survivorship and Outcomes committee. Eleanor is involved in multiple research activities, including the co-Principle Investigator of the prospective study involving the outpatient delivery of High-Dose Methotrexate in patients with Osteosarcoma.
MD, PhD, Clinical Professor, Endocrinology and Diabetes Unit, British Columbia’s Children’s Hospital, and University of British Columbia, Vancouver, BC
Access to Medicines in Pediatric Endocrinology and Diabetes: WHO and National Essential Medicines List
Dr. Chanoine is a Pediatrician who graduated from Belgium in 1982. He joined the University of British Columbia in 1998 as Clinical Professor and Head of the Endocrinology and Diabetes Unit at British Columbia’s Children’s Hospital.
His previous experience includes a fellowship at the University of Massachusetts Medical Center in Worcester, USA; Pediatric Endocrinologist at Hôpital des Enfants Reine Fabiola in Brussels; and Medical Director for Novo Nordisk Belgium.
Dr Chanoine is principal investigator of “Healthy Buddies”, a peer-led curriculum aiming at preventing the development of overweight in elementary school children and initiated the LiGHT project (Living Green, Healthy and Thrifty), a web-based program that emphasizes the beneficial effects of weight management on health, global environment and personal finances.
He is increasingly active in Global Health in the field of Pediatric Endocrinology and Diabetes in resource-constrained settings. Dr Chanoine is presently Secretary General of Global Pediatric Endocrinology and Diabetes (www.globalpedendo.org), an international non-profit organization that aims at promoting Pediatric Endocrine care in low income countries and Chair of the International Relations Council at the Pediatric Endocrine Society.
Julia von Oettingen
MD, PhD, MMSc, FRCP, Pediatric Endocrinologist, Montreal Children’s Hospital; Assistant Professor, Department of Pediatrics, McGill University Health Centre, Montreal, QC
The Pediatric Endocrinology Education Program for Haiti (PEEP-H): Opportunities for Health Care Professionals to get Involved in Global Health
Dr. Julia von Oettingen is a pediatric endocrinologist at the Montreal Children’s Hospital and Assistant Professor at McGill University. She obtained her MD (2008) and PhD (2009) degrees from the University of Leipzig medical school in Germany, and a master of medical sciences degree (2015) from Harvard Medical School. She completed her residency in pediatrics at the Massachusetts General Hospital for Children, and her fellowship in pediatric endocrinology at Boston Children’s Hospital, both in Boston, USA. Dr. von Oettingen has been working in Liberia and Haiti to establish pediatric diabetes care, and is a site adviser to the International Diabetes Federation’s Life for a Child program in Liberia and Haiti. She is the founding medical director of a pediatric chronic care center in Haiti, and technical adviser for pediatric endocrinology to Partners in Health. She is a member of the Pediatric Endocrine Society International Relations Council where she leads the Haiti sub-group, including the development of the Pediatric Endocrinology Education Program for Haiti. Julia recently joined the Executive Committee of Global Pediatric Endocrinology Diabetes (GPED). Her clinical and research interests are diabetes and endocrine conditions in non-Caucasian populations, and chronic care delivery in resource limited settings.
MD, FRCPC, Staff Endocrinologist, The Hospital for Sick Children; Associate Scientist, Sick Kids Research Institute; Associate Professor, University of Toronto, Toronto, ON
DEBATE: Should Screening or Celiac Disease in Asymptomatic Patients with Type1 Diabetes be Routinely Done? (Pro side)
Farid Mahmud received his medical degree at The University of Alberta, Edmonton. He trained in Paediatric Endocrinology and Metabolism at The Mayo Clinic, Rochester, Minnesota, USA. He is currently Staff Physician in the Division of Endocrinology, Department of Paediatrics, Associate Professor at the University of Toronto and Associate Scientist at The Hospital for Sick Children Research Institute.
Dr. Mahmud’s overall research focus is diabetes, clinical and translational research relating to co-morbid auto immune conditions, and early evaluation and prevention of related complications. His research interests include:
• Interventions in High Risk Pediatric groups including Type 1 and Type 2 Diabetes to alter CVD risk. As part of an international, double-blind, randomized control trial, Dr. Mahmud serves as Principal Investigator of the Adolescent Diabetes Cardio-Renal Intervention Trial (AdDIT) Expansion in Canada
• Assessment of co-morbid autoimmune conditions: impact of Celiac Disease and Type 1 Diabetes. Dr. Mahmud has a longstanding interest in Celiac Disease as an association with Type 1 Diabetes. He serves as Principal Investigator of a dietary intervention study (Celiac Disease and Diabetes – Dietary Intervention and Evaluation Trial (CD-DIET)
• Evaluation of social determinants of health on paediatric chronic disease.
MD, FRCPC, Assistant Professor, Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS
DEBATE: Should Screening or Celiac Disease in Asymptomatic Patients with Type1 Diabetes be Routinely Done? (Con side)
Dr. Teresa Pinto is a Pediatric Endocrinologist at the IWK Health Centre and Assistant Professor of Pediatrics at Dalhousie University in Halifax, NS. Born and raised in Montreal, she completed medical training at McGill University with a residency in Pediatrics at Dalhousie University and fellowship training in Endocrinology and Metabolism at the University of Ottawa. She then completed a research fellowship at Auckland University in Auckland, New Zealand. She is expanding her research portfolio in the areas of diabetes and endocrinology with a particular interest in obesity and Type 2 diabetes.
PhD, Professor and Canada Research Chair in Metabolic Diseases, Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON
Novel Pathways Regulating Energy Expenditure: Potential Implications for Treating Obesity and the Metabolic Syndrome
Dr. Steinberg completed his PhD at the University of Guelph (2002) and postdoctoral fellowship at the University of Melbourne (2007) before establishing his own laboratory at McMaster University where he is currently a Professor in the Department of Medicine and Co-Director of the Metabolism and Childhood Obesity Research Program. Dr. Steinberg’s research uses advanced techniques in biochemistry, molecular biology and physiology in novel animal models and clinical populations, to unravel fundamental mechanisms by which energy sensing, endocrine factors and therapeutics regulate metabolism. Over the last 5 years Dr. Steinberg has discovered how metabolic stressors such as exercise, fasting, aging and commonly used medications for type 2 diabetes elicit their glucose lowering effects. More recently the Steinberg lab has discovered a new way to turn on the body’s metabolic furnace to burn calories and reduce blood sugar levels. His detailed understanding of the mechanisms regulating cellular energy sensing has wide ranging implications for the treatment of many common chronic diseases including obesity, type 2 diabetes, cardiovascular disease and cancer. He has over 130 publications in leading scientific journals such as Nature Medicine and is a member of the Royal Society of Canada College of New Scholars, Artists and Scientists.
Professor and Chair, Department of Kinesiology, McMaster University, Hamilton, ON
Physiological and Health Adaptations to Interval Exercise Training
Martin Gibala is a professor and chair of McMaster’s Department of Kinesiology. His research on the physiological and health benefits of high-intensity interval training has attracted immense scientific attention and worldwide media coverage. Gibala has authored over 100 peer-reviewed articles, the results of which have been featured by outlets including The New York Times, TIME and NBC News. Penguin Random House will publish his first book, “The One-Minute Workout”, in February, 2017. Gibala has received three awards for teaching excellence from the McMaster Students Union as well as the President’s Award for Excellence in Graduate Student Supervision.
MD, FRCPC, Research Chair in Pediatric Bone Health, Associate Professor of Pediatrics, University of Ottawa, Ottawa, ON, Canada
The Diagnosis and Management of Metabolic Bone Diseases in Childhood: An Update for Endocrinologists
Dr. Leanne Ward is an Associate Professor of Pediatrics at the University of Ottawa where she has held a Research Chair in Pediatric Bone Health since 2010. She is the Medical Director of the Pediatric Bone Health Clinical and Research Programs at the Children’s Hospital of Eastern Ontario and a pediatric endocrinologist within the Division of Endocrinology and Metabolism. Dr. Ward’s research program is dedicated to the study of bone development and the treatment of bone disorders in children. She has been the principal investigator of the “STOPP” research program (STeroid-induced Osteoporosis in the Pediatric Population), a pan-Canadian project funded by the Canadian Institutes of Health Research to evaluate the effect of glucocorticoids on bone health in children with chronic illnesses. She has served as an endocrinology and bone health advisor to numerous national and international organizations on various aspects of skeletal health in children, including the Centres for Disease Control Clinical Care Guidelines for Duchenne Muscular Dystrophy. Dr. Ward has received a number of awards for her work in pediatric bone health, including a Canadian Child Health Clinician Scientist Career Development Award, a Canadian Institutes for Health Research New Investigator Award, a Canadian Child Health Clinician Scientist Career Enhancement Award, and two, five-year Research Chairs in Pediatric Bone Health (University of Ottawa, 2010 and 2015).
MD, FRCPC, Community Pediatric Endocrinologist; Clinical Assistant Professor, Department of Pediatrics, University of Calgary, Calgary, AB
Community Pediatric Endocrine Practise: Life Outside of Academia
Karin Winston completed medical school at the University of Calgary and pediatric residency in London, Ontario before returning to Calgary to complete a pediatric endocrine fellowship. In addition to general pediatric endocrinology, her interests to date include obesity and transitioning pediatric patients to adult care. Karin has completed a Master’s degree in Community Health Science. Her thesis focused on work done with a video targeted at improving transition to adult care for patients with type 1 diabetes. It had been her intention to pursue a career in academic pediatric endocrinology but the opportunity for a community practice came at the right time and has been an exciting and rewarding journey.
MD, PhD, Professor, Head of Endocrine Unit, Hôpital Saint-Antoine, University Pierre and Marie Curie, Paris, France
Hormonal Replacement Therapy in Adolescents and Young Women
Sophie Christin-Maitre received her medical degree at The University of Paris, France. She trained in Endocrinology and reproductive medicine in Paris. She has been a fellow in Reproductive Endocrine Unit at Massachusetts General Hospital, Harvard medical School, Boston, USA Rochester. She is currently head of the Endocrine Unit, in St Antoine hospital in Paris. She is in charge of a Center for rare endocrine diseases. She belongs to the research unit INSERM U933 and she is Professor at the University Pierre and Marie Curie (UMPC) – Paris Sorbonne.
Research Activities Dr. Christin-Maitre’s overall research focus is clinical and translational research relating to female and male reproduction. Her research interests include:
– Primary ovarian insufficiency (POI), essentially finding genes involved in ovarian insufficiency. She is the principal investigator of a French national research project studying families of POI patients.
– Turner syndrome, as a large cohort of adult patients are being followed in the Unit, especially spontaneous pregnancies and aortic evolution in Turner syndrome patients.
– Female contraception and hormonal replacement therapy..
MD, FRCPC, Program Director, Pediatric Endocrinology Training Program, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON
Disorders of Sex Development: Recent Clinical Advances
Diane Wherrett received her medical degree at Queen’s University in Kingston, Ontario. She trained in Paediatrics and Paediatric Endocrinology at The Hospital for Sick Children, Toronto and did a research fellowship in the immunology of type 1 diabetes at Stanford University. She is currently a Staff Physician in the Division of Endocrinology, Department of Paediatrics, Associate Professor at the University of Toronto and Program Director, Paediatric Endocrinology Training Program at The Hospital for Sick Children. She is the Centre Director of the Canadian site of the NIH multicentre clinical trial group, Type 1 Diabetes TrialNet, and a member of the TrialNet Steering Committee. In addition, she is interested in the care of children with disorders of sex development.
PhD, Post-doctoral Fellow, Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC, USA
New Insights Into Molecular Aspects of Gonadal Development
Dr. Barbara Nicol is a post-doctoral fellow in the Reproductive Developmental Biology Group, lead by Dr. Humphrey Yao, at the National Institute of Environmental Health Science (NIEHS/NIH), in North Carolina, USA. She joined Humphrey Yao’s lab in 2012, after completing her PhD in Biology at the University of Rennes1, France in 2011. Her research focuses on identifying the molecular mechanisms involved in sex determination and ovarian development using the mouse model.